急性胰臟炎

[大敦寵物醫院]

小雁 : 戴醫師您好~

先感謝您上次回答我的問題~ 一直想上來告訴您卻一直沒有時間!

我家兩隻狗寶貝同時間急性胰臟炎,經過住院19天目前兩隻都已經康復出院了!

在狗狗住院第十六天持續用支持療法卻一直無法讓病情好轉之下,我的醫師用了Sandostatin.隔兩天再度血測兩個消化脢指數迅速下降,而且兩隻寶貝狗的胰臟指數都接近正常~ 第十九天完全穩定就出院囉^_^

然後半個多月前,我網友的狗狗也一樣胰臟炎住院.一星期內都時好時壞.後來也是用Sandostatin之後三天內出院!!

呵呵…或許這種藥物不見得讓每隻狗狗都能迅速恢復,至少能夠減少支持療法的時間, 看到寶貝痛得發抖的樣子, 想起來都鼻酸.

不知道耶…這種藥真的救了我所知道的三隻寶貝狗,所以上來跟您說一下^_^ 也許哪天遇上了難搞定的胰臟炎問題可以幫得上忙.

另外重點在: 謝謝您不厭其煩的幫大家解決問題~

大敦寵物醫療中心院長戴更基醫生 : 謝謝你提供的經驗，你的狗好了就好。

不過，這個要不是用來治療胰臟炎的，而是用來治療腫瘤的。以下是新版的藥物說明，我還是不建議使用
此藥的成份為Octreotide acetate.
你說得三隻狗都好了，如果都是胰臟的腫瘤引起，使用這個藥當然會好，但是如果是胰臟炎，我擔心的反而是未來。

Octreotide 1006
OCTREOTIDE ACETATE
Prescriber Highlights –
‧ Injectable long acting somatostatin analog that may be useful for adjunctive
treatment of insulinomas and gastrinomas
‧ Limited experience, but appears safe in dogs/ferrets
‧ Requires multiple daily SC injections
‧ No information for dogs/ferrets on depot IM form
‧ Expensive (especially in large dogs)
‧ May affect GI fat absorption
Chemistry – Octreotide acetate is a synthetic polypeptide related to somatostatin. It is
commercially available in injectable forms for subcutaneous or IV injection, and as a extended
release suspension for IM administration.
Storage/Stability/Compatibility – When stored at room temperature and protected from light
octreotide acetate injection is stable for 14 days. For long term storage, keep refrigerated. If
injecting solution that has been in the refrigerator, allow to come to room temperature in the
syringe before injecting. Do not use artificial warming techniques. It is recommended to use
multidose vials within 14 days of initial use.
Pharmacology – Octreotide is a synthetic long acting analog of somatostatin. It inhibits the
secretion of insulin (in both normal and neoplastic beta cells), glucagon, secretin, gastrin and
motilin.
Uses/Indications – Octreotide may be useful in the adjunctive treatment of hyperinsulinemia in
patients with insulinomas (especially dogs, ferrets). Response is variable, presumably dependent
on whether the tumor cells have receptors for somatostatin present. Octreotide may also be
useful in the diagnosis and symptomatic treatment of gastrinomas in dogs or cats.
Pharmacokinetics – Octreotide is absorbed and distributed rapidly from the injection site after
SC administration. Half lives in humans average about 2 hours with a duration of effect up to 12
hours. Treated dogs or ferrets generally require 2-3 injections per day to maintain blood glucose.
About 32% of a dose is excreted unchanged in the urine and patients with severe renal
dysfunction may need dosage adjustment.
Contraindications/Precautions/Reproductive Safety – Octreotide is contraindicated in patients
hypersensitive to it. It should be used with caution in patients with biliary tract disorders.
It is unknown if it is safe to use in pregnancy or if it enters maternal milk.
Adverse Effects/Warnings – Very limited experience in domestic animals. Appears to be well
tolerated thus far. GI effects (including biliary tract effects) are most commonly noted in human
patients, particularly acromegalics.
Overdosage/Acute Toxicity – Serious adverse effects are unlikely. Human subjects have
received up to 120 mg IV over 8 hours with no untoward effects.
Drug/Food Interactions – Octreotide may alter the absorption of dietary fats in some patients.
Clinical significance is unclear.

[作者]

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